The lectures on irritability here published were held at the University of Yale in October, 1911. The physiologist, the zoölogist, the botanist, the psychologist, the pathologist, have to deal, day in, day out, with the effects of stimulation on the living substance. No living substance exists without stimulation. In the vital manifestations of all organisms the interplay of the most varied stimuli produces an enormous and manifold variety of effects. Experimental biological science employs artificial stimulation as the most important aid in the methodic production of certain effects of stimulation. The number of researches in which special effects of stimulation are treated is endless. Nevertheless the systematic investigation of the effects of stimulation have, curiously enough, been strangely neglected. 

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